Fas apoptotic inhibitory molecule 2 (FAIM2)

Fas apoptotic inhibitory molecule 2 (FAIM2) is a neuronally expressed transmembrane protein belonging to the TMBIM (Transmembrane BAX Inhibitor Motif-containing) family, also known as lifeguard proteins. FAIM2’s primary function is to protect neuronal cells from Fas (CD95) receptor-mediated apoptosis by directly interfering with downstream signaling, particularly caspase-8 activation, thereby preventing cell death following various stress conditions. The protein also interacts with other apoptosis-related factors, including p53 and HSP90, and may regulate calcium channel activity and autophagy. FAIM2 is constitutively expressed in the nervous system, with upregulation or downregulation affecting vulnerability to neurodegenerative conditions, retinal degeneration, and some metabolic disorders. It is a potential therapeutic target for neuroprotective strategies, though its dual regulatory roles in both cell death and regeneration highlight the need for precise modulation to avoid interfering with adaptive neurogenesis and repair mechanisms.

Other names

Protein lifeguard 2LFG2KIAA0950LFGNMP35LIFEGUARDTMBIM2Neural membrane protein 35Transmembrane BAX inhibitor motif-containing protein 2NGP35

Drugs targeting FAIM2 would likely function through inhibition of the Fas/CD95-mediated extrinsic apoptotic pathway, interfering with caspase-8 activation downstream of Fas receptor signaling, modulation of intracellular calcium homeostasis, or regulation of autophagy/lysosomal function via LC3 interaction.