FAS-associated death domain protein (FADD)

FAS-associated death domain protein (FADD) is a 23 kDa adaptor protein consisting of two main domains: a C-terminal death domain and an N-terminal death effector domain. It functions by bridging death receptors such as Fas (CD95) with initiator caspases (notably procaspase-8 and -10), forming the death-inducing signaling complex (DISC) that triggers apoptosis. FADD also regulates necroptosis, autophagic cell death, cell proliferation, and immune system responses. It is encoded by the FADD gene on chromosome 11q13.3, and its expression and function are crucial for proper cell death signaling, immune homeostasis, and genome surveillance. Dysregulation or mutation of FADD is implicated in cancer, autoimmunity, and infectious diseases.

Other names

MORT1Fas-associated protein with death domainFADD

Promote or inhibit death receptor signaling, leading to apoptosis. Induction of cell cycle arrest. Potential inhibition of FADD for drug-resistant cancer therapy (proposed, not established clinically).