Fas binding factor 1 (FBF1)

Fas binding factor 1 (FBF1) is a keratin-binding protein essential for the assembly of apical junctions and establishment of epithelial cell polarity in humans[1][10]. It is located at the apical junction complex and interacts with proteins such as PARD3 to mediate these effects[10][1]. FBF1 also plays a critical role in ciliogenesis by being part of the ciliary transition fiber, contributing to the assembly of cilia in epithelial cells[1][3][10]. Mutations in the FBF1 gene are associated with developmental disorders such as hydrolethalus syndrome[1]. FBF1 is not classified as a receptor, enzyme, transporter, or major therapeutic target, so it is not directly associated with known drug interactions or mechanisms of pharmacological intervention. The submitted query also mentions several alternative forms or synonyms (such as ALB, protein albatross, FBF-1). Some of these, like "ALB," can ambiguously refer to unrelated proteins (such as albumin), which is not related biologically to FBF1. FBF1 should not be confused with Fas-associated factor 1 (FAF1), which is a distinct protein involved in apoptotic signaling and part of the Fas-death-inducing signaling complex[2][4][8]. FBF1’s role is structural and regulatory in epithelial and ciliary biology, not in Fas-mediated apoptosis pathways[1][3][10].

Other names

Fas binding factor 1FBF1ALBKIAA1863FBF-1FLJ00103Albatrossprotein albatross