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Target intelligence / Profile preview
Fas ligand (FasL)
- Target
- FasL
- Molecular classification
- Type-II transmembrane protein, Tumor necrosis factor (TNF) superfamily
01
Overview
Fas ligand (FasL), also known as CD95L or Apo-1L, is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) superfamily. It plays a central role in regulating apoptosis and immune system homeostasis by binding to its receptor Fas and triggering a cascade of events leading to programmed cell death. Dysregulation of FasL is implicated in autoimmune diseases and tumor immune evasion.
- Other names
- CD95LApo-1L
02
Mechanism of action
Binding to Fas receptor, DISC formation, caspase cascade activation, apoptosis
03
Biological functions
ApoptosisImmune regulationNegative selection during thymocyte developmentActivation-induced cell deathMaintenance of peripheral toleranceInduction of apoptosis in infiltrating lymphocytes
04
Disease associations
Autoimmune diseases (e.g., systemic lupus erythematosus)Lymphoproliferative disordersTumor immune evasion
05
Safety considerations
Potential for autoimmunity if FasL function is inhibitedRisk of immune suppression if FasL function is overstimulated
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