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Target intelligence / Profile preview
Fas Ligand Protein (CD95 Ligand)
- Target
- CD95 Ligand
- Molecular classification
- Tumor necrosis factor (TNF) superfamily, Type-II transmembrane protein
01
Overview
Fas Ligand (CD95 Ligand) is a type-II transmembrane protein belonging to the TNF superfamily. It is primarily expressed by cytotoxic T lymphocytes and natural killer cells and plays a critical role in regulating immune homeostasis by inducing apoptosis in target cells expressing the Fas receptor (CD95). This interaction is crucial for eliminating virus-infected cells, cancer cells, and autoreactive T cells, as well as maintaining immune privilege. Dysregulation or mutations in FasL can lead to autoimmune diseases like ALPS.
- Other names
- FasLCD95LApo-1L
02
Mechanism of action
Binding to the Fas receptor (CD95/TNFRSF6), triggering programmed cell death (apoptosis) via DISC formation and caspase activation.
03
Biological functions
ApoptosisRegulation of immune homeostasisElimination of virus-infected cellsElimination of cancer cellsElimination of autoreactive T cellsMaintenance of immune privilegePeripheral deletion of activated lymphocytesCell deathImmune response
04
Disease associations
Autoimmune diseasesAutoimmune lymphoproliferative syndrome (ALPS)
05
Safety considerations
Dysregulation can lead to autoimmune diseases.Potential for off-target effects due to broad expression.
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