Fasciculation and elongation protein zeta 2 (FEZ2)

Fasciculation and elongation protein zeta 2 (FEZ2) is a human protein encoded by the FEZ2 gene, part of the FEZ family with homologs in other species (e.g., *C. elegans* UNC-76, human FEZ1)[1][3][4][6]. It is primarily characterized as an **intrinsically disordered hub protein** with extensive protein-protein interactions, especially acting as a bivalent cargo transport adaptor for kinesin-based intracellular movement[3][5]. FEZ2 exhibits ubiquitous tissue expression, in contrast to FEZ1, which is mostly neuronal, suggesting broader cellular functions including potential nuclear and cytoplasmic roles[2][7]. It contributes to axonal bundling, elongation, and intracellular transport, and is implicated in **neuronal development**, neurological disorders, autophagy, and viral infection responses, though it is not currently recognized as a direct therapeutic target or biomarker[3][5][7]. There is no evidence connecting FEZ2 to any approved drugs or specific safety issues at present.

Other names

FEZ2Fasciculation and elongation protein zeta-2Zygin IIZygin-2HUM3CLpre-T/NK cell associated protein (3Cl)zygin 2zygin II

None established. No mechanism of drug action targeting FEZ2 is reported.