Fascin actin-bundling protein 3 (FSCN3)

Fascin actin-bundling protein 3 (FSCN3) is a member of the fascin family of small, globular actin-bundling proteins with four β-trefoil domains, each containing distinct actin-binding sites[2][3][4]. Fascin proteins organize actin filaments into tightly packed, well-ordered bundles that support membrane protrusions (filopodia, microspikes, invadopodia) involved in cell motility, migration, and invasion[1][2][3]. Fascin-3 has tissue-specific expression, primarily in the testis, where it is thought to play a role in spermatogenesis and the formation of cytoskeletal structures essential for sperm development. Dysregulation of fascin proteins (especially fascin-1) is implicated in cancer metastasis and is being investigated as a therapeutic target; inhibitors such as G2 disrupt actin bundling by interfering with fascin’s actin-binding sites[3]. Fascin proteins, including fascin-3, bind actin filaments through two major actin-binding sites and may dimerize for bundling activity[2][3][4].\n\nIf you need more information specific to fascin-3's testicular roles or related disease associations, further literature review on FSCN3 is recommended. If your context was fascin-1 (the most well-studied isoform in cancer), please clarify, as much research and drug targeting focuses on fascin-1[2][3].

Other names

Fascin-3Testis fascinFSCN3

Allosteric inhibition of actin bundling by fascin inhibitors (e.g., G2 disrupts F-actin cross-linking by binding fascin and blocking actin-binding interfaces[3].)