Fat-soluble vitamin delivery

Fat-soluble vitamin delivery encompasses the multi-step physiological process required for the assimilation, transportation, and distribution of vitamins A, D, E, and K in the human body. These vitamins require dietary fats and bile for efficient intestinal absorption[1][2][5], followed by incorporation into micelles, uptake by enterocytes, packaging into chylomicrons, and transport via the lymphatic system before entering the bloodstream[1][2][5]. In the circulation and within tissues, several transport proteins—including albumin, lipoproteins, scavenger receptor class B type I (SR-BI), CD36, Niemann-Pick C1-like 1 (NPC1L1), and intracellular binding proteins (e.g., CRBP for vitamin A, α-TTP for vitamin E)—facilitate their cellular uptake and targeting to specific pathways or organelles[2][3][4][5]. Impairment of any component in this pathway can lead to vitamin deficiency and disease[5]. In summary, "fat-soluble vitamin delivery" refers to a complex physiological process involving multiple protein classes and steps—it is not a discrete, druggable molecular target[1][2][3][4][5].

Other names

fat-soluble vitamin absorptionfat-soluble vitamin transportfat-soluble vitamin uptake