Fat storage

Fat storage is a complex physiological process characterized by the synthesis and accumulation of triacylglycerols within specialized lipid droplets of adipocytes [1]. This mechanism is vital for energy homeostasis, as it allows the body to store metabolic fuel during caloric excess and mobilize it during energy deficits [2]. In addition to energy buffering, fat storage in adipose tissue serves as an endocrine organ, secreting signaling molecules like leptin and adiponectin that regulate appetite, insulin sensitivity, and systemic metabolism [3]. While 'Fat storage' is colloquially used to describe a therapeutic focus, it is a physiological pathway and biological state rather than a single molecular target [4]. Pharmacological strategies to address pathological fat storage, such as obesity, involve targeting various specific components including gastrointestinal lipases (e.g., Orlistat), GLP-1 receptors (e.g., Semaglutide), or PPAR-gamma (e.g., Pioglitazone) [1, 5]. Excessive accumulation of fat is a primary driver of chronic metabolic conditions, including type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease [4].

Other names

Lipid storageAdipogenesisTriacylglycerol accumulationLipogenesisFat deposition

Modulation of lipid absorption via gastric and pancreatic lipase inhibition, regulation of energy intake through GLP-1 and GIP receptor agonism, and enhancement of lipid storage capacity and insulin sensitivity through PPAR-gamma activation.