Fat Synthesis Pathway (FAS)

The fat synthesis pathway, or fatty acid synthesis, is an anabolic process that produces fatty acids from smaller precursors, primarily acetyl-CoA. It occurs in the cytosol of liver, adipose tissue, and mammary glands. The pathway converts excess carbohydrates and proteins into fatty acids for energy storage as triglycerides. Key enzymes include acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). Regulation involves allosteric and covalent modification, as well as hormonal control. Dysregulation can contribute to metabolic diseases.

Other names

Fatty Acid Synthesis PathwayLipogenesis

Inhibition of enzymes involved in fatty acid synthesis, such as Acetyl-CoA Carboxylase (ACC)