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Target intelligence / Profile preview
Fatty Acid Amide Hydrolase 1 (FAAH1)
- Target
- FAAH1
- Molecular classification
- Enzyme, Serine hydrolase, Amidase signature family, Integral membrane protein
01
Overview
Fatty acid amide hydrolase 1 (FAAH1) is an integral membrane enzyme that hydrolyzes fatty acid amides, including the endocannabinoid anandamide and the sleep-inducing lipid oleamide. By breaking down these signaling molecules, FAAH1 terminates their biological activity, regulating processes like pain, inflammation, mood, appetite, and sleep. FAAH1 inhibitors are being explored for therapeutic use against chronic pain conditions and anxiety disorders.
02
Mechanism of action
Inhibition of FAAH1 increases levels of endogenous fatty acid amides like anandamide by preventing their degradation.
03
Biological functions
Hydrolysis of fatty acid amidesRegulation of endocannabinoid signalingTermination of lipid signalingPain modulationInflammation regulationMood regulationAppetite regulationSleep induction
04
Disease associations
Chronic painAnxiety disordersNeurodegenerative diseasesInflammation
05
Safety considerations
Potential psychoactive side effects due to elevated endocannabinoid levels, although likely reduced compared to direct cannabinoid receptor agonists.
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