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Fatty Acid Beta-Oxidation Pathway (FAO)

Target: FAO
Molecular classification: Metabolic pathway

Overview

The fatty acid beta-oxidation pathway is a central metabolic process by which fatty acids are broken down in cells to generate energy. This catabolic pathway occurs primarily in the mitochondria of eukaryotic cells (and in the cytosol of prokaryotes) and involves sequential removal of two-carbon units from fatty acyl-CoA molecules, producing acetyl-CoA, NADH, and FADH₂. The acetyl-CoA produced then enters the tricarboxylic acid (TCA) cycle for further oxidation and ATP generation.

Other names: β-oxidationFatty acid oxidation

Mechanism of action

N/A

Biological functions

Energy productionFatty acid catabolismAcetyl-CoA production

Disease associations

Metabolic disordersObesityMetabolic syndrome

Safety considerations

Defects in FAO can lead to metabolic diseases (e.g., MCADD)

Interacting drugs

Malonyl-CoA (endogenous regulator)

2 more in the full profile.

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