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Fatty acid-binding protein, adipocyte (FABP4)
- Target
- FABP4
- Molecular classification
- Fatty acid-binding protein (FABP)
01
Overview
FABP4 is a cytosolic lipid chaperone highly expressed in adipocytes, playing a crucial role in fatty acid uptake, storage, and mobilization. It is also involved in regulating inflammation and is associated with various metabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. FABP4 facilitates the trafficking of nonesterified fatty acids between cellular compartments and influences gene expression relevant to metabolism, inflammation, and lipid homeostasis.
- Other names
- A-FABPaP2
02
Mechanism of action
Binding and transport of long-chain fatty acids and retinoic acid, influencing gene expression and interacting with lipolytic enzymes (HSL, ATGL).
03
Biological functions
Lipid storageLipid oxidationFatty acid transportRegulation of lipolysisModulation of inflammatory responsesGene expression regulation
04
Disease associations
Metabolic SyndromeObesityType 2 Diabetes Mellitus (T2DM)Nonalcoholic Fatty Liver Disease (NAFLD)Coronary Artery DiseaseAtherosclerosisInflammation
05
Biomarkers
Serum A-FABP/FABP4 levels (predictive of metabolic syndrome risk)
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