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Fatty acid binding protein 4 (FABP4)
- Target
- FABP4
- Molecular classification
- Intracellular lipid chaperone, Fatty acid-binding protein family
01
Overview
FABP4 is a member of the fatty acid-binding protein family, primarily expressed in adipocytes and macrophages. It plays important roles in lipid metabolism, energy homeostasis, and inflammation. It facilitates intracellular transport of fatty acids, regulates lipid storage and mobilization, and modulates PPARγ activity. Elevated circulating levels are associated with obesity, insulin resistance, and cardiovascular disease. It is also implicated in cancer progression.
- Other names
- Adipocyte FABPA-FABPAdipocyte P2aP2
02
Mechanism of action
Therapeutic targeting/inhibition of FABP4 is proposed for treatment/prevention strategies against metabolic diseases such as diabetes mellitus or cardiovascular disorders due to its central role linking lipid handling to inflammation/metabolic dysfunctions
03
Biological functions
Lipid transportRegulation of lipid metabolismRegulation of glucose metabolismModulation of PPARγ activityAdipokine signaling
04
Disease associations
ObesityInsulin resistanceHypertensionCardiac dysfunctionHeart failureCoronary artery diseaseMetabolic syndromeAtherosclerosisCancer
05
Biomarkers
Peripheral artery disease prognosisCardiometabolic risk assessmentAtherosclerotic plaque vulnerability characterizationInsulin resistance/diabetes mellitus monitoringElevated plasma levels
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