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Target intelligence / Profile preview
Fatty Acid-Binding Protein 5 (None)
- Target
- None
- Molecular classification
- Lipocalin, Fatty Acid Binding Protein
01
Overview
Fatty acid-binding protein 5 (FABP5), also known as epidermal or cutaneous FABP, is a member of the fatty acid binding protein family. This small, cytoplasmic protein binds long-chain fatty acids and other hydrophobic ligands, playing a central role in lipid metabolism and transport. Overexpression or dysregulation of FABP5 has been linked with several diseases including psoriasis, metabolic disorders, and cancer. Targeting FABP5 could have therapeutic potential for conditions involving dysregulated endocannabinoid signaling or keratinocyte proliferation disorders.
- Other names
- FABP5Epidermal FABPCutaneous FABP
02
Mechanism of action
Phytocannabinoids inhibit endocannabinoid uptake by targeting FABP5. Delivery of retinoic acid to nuclear receptors like PPARβ/δ, promoting cell proliferation/survival. Modulation of docetaxel sensitivity in prostate cancer cells.
03
Biological functions
Intracellular fatty acid transportEndocannabinoid transportLigand delivery to nucleusLipid metabolismRegulation of prostaglandin E2 biosynthesisRetrograde endocannabinoid signaling
04
Disease associations
PsoriasisObesityType II diabetes mellitusMetabolic disordersBreast cancerProstate cancer
05
Interacting drugs
THC
2 more in the full profile.
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