Fatty acid-binding protein from Schistosoma mansoni (Sm14)

Fatty acid-binding protein from Schistosoma mansoni (Sm14) is a cytosolic protein essential for the parasite's lipid metabolism and survival, as S. mansoni is unable to synthesize fatty acids and relies on host-derived lipids[1][2][4]. Sm14 binds and transports fatty acids (e.g., oleic acid and arachidonic acid), with structural studies showing specificity for arachidonic acid due to a unique binding mode and affinity[1][2][4]. It plays a critical role in the parasite's ability to synthesize prostaglandins, aiding immune evasion. Sm14 is a leading candidate antigen for vaccine development against schistosomiasis, one of the world's most prevalent parasitic diseases[1][2][4][5]. Its functional importance, immunogenicity, and unique structural features make it both a molecular probe and a promising target for controlling S. mansoni infection.

Other names

Sm14Schistosoma mansoni fatty acid-binding proteinS. mansoni FABPSmFABP

Vaccine antigen: immune system stimulation upon immunization with recombinant Sm14 leads to protective responses against schistosomiasis. Lipid binding/modulation: competitive binding of host fatty acids (including oleic and arachidonic acid), crucial for parasite survival.