Fatty acid metabolism enzyme

Fatty acid metabolism enzymes comprise a network of enzymes catalyzing the activation, transport, synthesis, and degradation of fatty acids. Major components include acyl-CoA synthetases (for activation), carnitine acyltransferases and transporters (for mitochondrial entry), and a group of enzymes conducting beta-oxidation (acyl-CoA dehydrogenase, enoyl-CoA hydratase, hydroxyacyl-CoA dehydrogenase, ketoacyl-CoA thiolase)[1][2][9]. Synthesis is driven by acetyl-CoA carboxylase and fatty acid synthase complexes[6][7]. Their regulation and activity control energy balance, lipid turnover, and cell membrane homeostasis. Dysregulation is implicated in cancer progression, metabolic syndrome, and cardiovascular disease risk[7][8][1]. Drugs increasingly target this enzyme network to modulate lipid metabolism for therapeutic benefit, but safety concerns include tissue-specific toxicity and profound effects on whole-body energy metabolism[2][6][7]. Note: The entry "Fatty acid metabolism enzymes" is not a unique molecular target. It is a generic category/term; for structured data, one should refer to individual enzymes such as carnitine palmitoyltransferase I (CPT1), acetyl-CoA carboxylase, or fatty acid synthase (FASN)[7][6][2].

Other names

Fatty acid metabolic enzymeFatty acid oxidation enzymeFatty acid synthesis enzymeBeta-oxidation enzymeLipid metabolism enzyme

Enzyme inhibition (blockade of fatty acid synthesis or oxidation); Enzyme activation (increase fatty acid oxidation); Allosteric modulation (e.g., citrate as allosteric activator for acetyl-CoA carboxylase)