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Target intelligence / Profile preview
Fatty Acid Synthase (FAS)
- Target
- FAS
- Molecular classification
- Enzyme
01
Overview
Fatty acid synthase (FAS) is a large, multifunctional enzyme complex responsible for the de novo synthesis of long-chain saturated fatty acids, primarily palmitate (C16:0), from acetyl-CoA and malonyl-CoA using NADPH as a reducing agent. It plays a central role in energy storage, membrane assembly and repair, and secretion of lipoprotein triglycerides. Overexpression or dysregulation of FAS has been linked to metabolic diseases and cancers, making it a potential therapeutic target.
- Other names
- FASNEC 2.3.1.85
02
Mechanism of action
Disruption of abnormal lipid metabolism by inhibiting fatty acid synthesis.
03
Biological functions
De novo lipogenesisEnergy homeostasisMembrane lipid productionFatty acid biosynthesis
04
Disease associations
ObesityDiabetesNon-alcoholic fatty liver diseaseCardiovascular diseaseCancer
05
Safety considerations
Potential for off-target effects due to the enzyme's essential role in normal cell function.Therapeutic challenges related to drug delivery and achieving sufficient target inhibition in vivo.
06
Interacting drugs
FAS inhibitors
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