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Target intelligence / Profile preview
Fatty Acid Synthase I Complex (FAS-I)
- Target
- FAS-I
- Molecular classification
- Enzyme, Multienzyme Complex
01
Overview
Fatty acid synthase I (FAS-I) is a large, multifunctional enzyme complex responsible for the de novo biosynthesis of long-chain saturated fatty acids, primarily palmitate (C16:0), from acetyl-CoA and malonyl-CoA in the presence of NADPH. FAS-I plays a central role in cellular metabolism by providing essential components for membrane synthesis, energy storage, and signaling molecules. Overexpression or dysregulation has been linked to diseases such as cancer, obesity, and non-alcoholic fatty liver disease. Many human cancers show elevated levels of FAS expression—making it an attractive target for anticancer therapies.
02
Mechanism of action
Inhibition of fatty acid synthesis
03
Biological functions
Fatty acid synthesisLipid metabolismMembrane biogenesisEnergy storage
04
Disease associations
CancerObesityNon-alcoholic fatty liver disease
05
Interacting drugs
Cerulenin
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