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Fatty Acid Synthetase Complex (FAS)
- Target
- FAS
- Molecular classification
- Enzyme, Multifunctional enzyme complex
01
Overview
The fatty acid synthetase complex (FAS) is a large, multifunctional enzyme complex responsible for the de novo synthesis of long-chain saturated fatty acids from acetyl-CoA and malonyl-CoA in the presence of NADPH. Its primary product is palmitate (C16:0). Plays a central role in lipid metabolism and dysregulation is linked to diseases such as cancer, obesity, and non-alcoholic fatty liver disease.
- Other names
- Fatty Acid Synthase
02
Mechanism of action
Inhibition of fatty acid synthesis
03
Biological functions
De novo synthesis of long-chain saturated fatty acidsLipid metabolismCell growthCell proliferation
04
Disease associations
CancerObesityNon-alcoholic fatty liver disease
05
Safety considerations
Potential for off-target effects due to broad metabolic roleImpact on normal fatty acid metabolism
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