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Target intelligence / Profile preview
Mitochondrial Fatty Acid Transport Protein (FATP)
- Target
- FATP
- Molecular classification
- Transporter, Enzyme, Membrane protein, Acyl-CoA synthetase
01
Overview
Mitochondrial fatty acid transport proteins (FATPs) are integral membrane proteins responsible for the uptake and activation of long-chain and very-long-chain fatty acids into cells and their subsequent transport into mitochondria for β-oxidation. They possess intrinsic acyl-CoA synthetase activity and are crucial for energy production from fats. Dysregulation of FATPs is implicated in various metabolic diseases.
- Other names
- Fatty Acid Transport ProteinSLC27 familyACSVL (Acyl-CoA synthetase very long-chain) family
02
Mechanism of action
Facilitates fatty acid transport and activation via acyl-CoA synthetase activity, promoting beta-oxidation.
03
Biological functions
Fatty acid transportAcyl-CoA synthesisRegulation of beta-oxidationCellular fatty acid uptakeMitochondrial fatty acid import
04
Disease associations
ObesityHepatic steatosisInsulin resistanceMetabolic syndromeIchthyosis premature syndrome
05
Safety considerations
Dysregulation can lead to metabolic disordersMutations can cause severe developmental defects
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