Fatty acid transport protein and CD36 receptor (FATP (for fatty acid transport protein), CD36 (for CD36 receptor))

Fatty acid transport proteins are a family of membrane-bound transporters (SLC27A1-6, FATP1-6) that facilitate the uptake of long- and very-long-chain fatty acids across the plasma membrane, often with fatty acyl-CoA synthetase activity. CD36, in contrast, is a multifunctional scavenger receptor (also called fatty acid translocase) that mediates cellular uptake of long-chain fatty acids, oxidized lipoproteins, and other ligands. CD36 is widely expressed (adipocytes, myocytes, macrophages, endothelial cells, platelets), supports both fatty acid transport and diverse signaling (including immune and metabolic pathways), and contributes to lipid homeostasis, taste perception, and inflammatory responses. Both protein classes have key roles in health and disease, including obesity, insulin resistance, cardiovascular disease, and cancer, but their molecular identities, genetics, and pharmacology are distinct and should be differentiated[1][2][3][5][7]. For most structured applications, “Fatty acid transport protein” (FATP, SLC27 family) and “CD36 receptor” (CD36, fatty acid translocase) should be mapped as separate targets.

Other names

FATPSLC27 familySLC27A1-6very long-chain acyl-CoA synthetase (particular isoforms)Fatty acid translocase (FAT)scavenger receptor class B member 2 (SR-B2)cluster of differentiation 36 (CD36)glycoprotein IV (GPIV)platelet glycoprotein IV

Inhibition of fatty acid uptake/transport (via receptor blockade or inhibition); Modulation of lipid signaling and metabolism; Modulation of inflammatory signaling (especially for CD36, as a pattern recognition receptor).