Fatty acyl-CoA reductase 2 (FAR2)

Fatty acyl-CoA reductase 2 (FAR2) is an enzyme that catalyzes the reduction of saturated (but not unsaturated) C16 or C18 fatty acyl-CoA substrates to their corresponding fatty alcohols[1][2][4]. This process is critical for fatty alcohol biosynthesis and lipid metabolism, with implications for cellular membrane composition and signaling. Genetic or functional changes in FAR2 have been implicated in the development of mesangial matrix expansion and chronic kidney disease[3][5]. FAR2 belongs to the short chain dehydrogenase/reductase (SDR) family and is known by several alternative names and symbols. No direct approved drugs or safety concerns have been commonly described for FAR2 based on currently available biomedical data.

Other names

Male sterility domain-containing protein 1MLSTD1FLJ10462SDR10E2HEL-S-81epididymis secretory protein Li 81short chain dehydrogenase/reductase family 10E member 2