FBN1 divergent transcript (FBN1-DT)

FBN1 divergent transcript (FBN1-DT) is a long noncoding RNA gene transcribed in the FBN1 genomic region but distinct from the protein-coding FBN1 gene responsible for fibrillin-1 production[7]. Unlike FBN1, which is well studied for its role in connective tissue diseases such as Marfan syndrome[1][3][5], FBN1-DT does not code for a protein and its biological function, expression profile, regulatory interactions, and relevance to human disease are currently uncharacterized in the literature. There is no evidence suggesting it is a therapeutic target, and it should not be confused with FBN1 itself. If you are searching for the canonical fibrillin-1 gene, refer to "Fibrillin-1 (FBN1)," a structural protein of microfibrils and a genetically validated disease target in Marfan syndrome and related disorders[1][3][5].

Other names

FBN1 divergent transcriptFBN1-DT