High-affinity immunoglobulin E receptor (Fc epsilon RI) (FcεRI)

The canonical target for "Immunoglobulin E-mediated mast cell activation" is the high-affinity immunoglobulin E receptor, known as Fc epsilon RI (FcεRI). This multimeric receptor is expressed on the surface of mast cells and basophils. When antigen-specific IgE antibodies bound to FcεRI are cross-linked by allergens, this triggers a signaling cascade leading to rapid degranulation of the cells. Degranulation releases preformed mediators such as histamine, proteases, cytokines, and chemokines that drive allergic symptoms including urticaria, bronchoconstriction, hypotension, and anaphylaxis[1][2][3][4][5]. Beyond immediate hypersensitivity reactions, sustained or repeated engagement can promote chronic inflammation seen in asthma and other allergic diseases. Therapeutic strategies targeting this pathway include anti-IgE antibodies like omalizumab that prevent IgE from binding to its high-affinity receptor on effector cells.

Other names

High-affinity IgE receptorFc epsilon RIFcεRIIgE receptor

Inhibition of IgE binding to FcεRI, preventing mast cell activation and degranulation[2][4]