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Target intelligence / Profile preview
Fc fragment of IgE receptor gamma polypeptide (FCER1G)
- Target
- FCER1G
- Molecular classification
- Receptor, Adapter protein, Immune receptor subunit
01
Overview
Fc fragment of IgE receptor gamma polypeptide (FCER1G) encodes the gamma chain subunit of the high affinity IgE receptor (FcεRI), which is a tetrameric receptor central to allergic reactions and type I hypersensitivity. The gamma chain contains an immunoreceptor tyrosine-based activation motif (ITAM) and acts as a signal transducer for multiple immunoreceptors in various immune cell types. It participates in the immune response, allergic inflammation, and cancer immune regulation
- Other names
- Fc epsilon receptor gamma chainFcεRI gamma chainFc fragment of IgE receptor IgFcepsilonRI gamma chain
02
Mechanism of action
Receptor signal transduction via immunoreceptor tyrosine-based activation motif (ITAM), activating downstream immune cell responses
03
Biological functions
Immune responseSignal transductionAllergic inflammationCancer immune infiltration
04
Disease associations
InflammationAllergyCancerOther immune-related diseases
05
Safety considerations
Potential risk of exacerbating allergic or inflammatory responses due to central role in immune activation
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