Fc fragment of IgG binding protein (FCGBP)

Fc fragment of IgG binding protein (FCGBP) is a secreted, cysteine-rich glycoprotein predominantly found in mucus-secreting epithelia of the gastrointestinal, respiratory, and reproductive tracts[2][4][5]. It is composed of multiple von Willebrand D domains, enabling covalent linkage to mucins, which contributes to the structural organization and protection of the inner mucus layer[2][1]. FCGBP is co-secreted with peptides such as TFF1 and TFF3, implicating it in mucosal defense mechanisms[2]. Altered expression of FCGBP is observed in various cancers and inflammatory conditions, and its high expression is associated with advanced tumor grade and poor prognosis in glioma[1]. FCGBP is also implicated as a diagnostic and prognostic biomarker in multiple disease states, reflecting its dual function in both barrier integrity and immune response modulation[1][2][5]. The molecular function of FCGBP is still being elucidated, especially regarding its precise roles in immunity and tumor biology[1][2].

Other names

Fc gamma binding proteinIgG Fc binding proteinFCGBPFcgammaBPFC(GAMMA)BPfcgamma-binding protein antigenHuman Fc gamma BPFc fragment of IgG binding proteinIgGFc-binding proteinLOC100133944LOC435957

Not established for drugs; mechanisms suggested involve modulation of immune infiltration or tumor microenvironment as part of immunotherapy-related research, but no approved FCGBP-targeted agents