Fc gamma receptor family (FcγR)

The Fc gamma receptor (FcγR) family consists of several cell surface glycoproteins that bind the Fc region of immunoglobulin G (IgG) antibodies, serving as a critical link between the adaptive and innate immune systems (Source: UniProt). These receptors are categorized into three main classes—FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16)—which are further divided into activating and inhibitory types based on their signaling motifs (Source: PMC4102151). Activating receptors, such as FcγRIIIa, mediate essential immune functions like antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis, while the inhibitory receptor FcγRIIb acts as a checkpoint to maintain immune homeostasis. In oncology, many therapeutic monoclonal antibodies are designed to optimize binding to activating}

Other names

Fc-gamma receptorFCGRCD16CD32CD64IgG Fc receptorLow affinity immunoglobulin gamma Fc receptor

Engagement of activating receptors (FcγRI, FcγRIIa, FcγRIIIa) to trigger antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP); competitive inhibition of IgG binding to prevent tissue destruction; and modulation of the inhibitory receptor FcγRIIb to regulate B-cell signaling and inflammatory responses (Source: PMC4102151, StatPearls).