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Target intelligence / Profile preview
High Affinity Immunoglobulin Gamma Fc Receptor I (CD64)
- Target
- CD64
- Molecular classification
- Receptor, Immunoglobulin superfamily, Fc receptor
01
Overview
CD64 (FcγRI) is a high-affinity receptor for the Fc region of IgG antibodies, constitutively expressed on monocytes and macrophages and inducible on neutrophils and eosinophils by cytokines. It plays a crucial role in linking antibody recognition to cellular responses, including phagocytosis, antigen presentation, ADCC, and cytokine production. It is therapeutically targeted in some cancer models due to its role in ADCC against tumor cells when engaged by therapeutic antibodies. Expression levels can be modulated by inflammatory cytokines.
- Other names
- Fc gamma receptor IFcγRIFcRIFc-gamma RIFCGR1ACD64 antigen
02
Mechanism of action
Activation of immune cells via binding to the Fc region of IgG antibodies, leading to phagocytosis, ADCC, cytokine release, and complement activation.
03
Biological functions
PhagocytosisAntigen presentationAntibody-dependent cellular cytotoxicity (ADCC)Cytokine production/secretionComplement activationImmune response
04
Disease associations
Autoimmune diseasesNeuropathiesCancer
05
Safety considerations
Overactivation can exacerbate autoimmune diseases.Aberrant immune activation.
06
Interacting drugs
Therapeutic antibodies
07
Biomarkers
Expression levels of CD64 can indicate disease activity or response to therapy.
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