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Fc gamma receptor Ib pseudogene (FCGR1BP)
- Target
- FCGR1BP
- Molecular classification
- Pseudogene, Immunoglobulin superfamily domain containing, Receptor (by sequence homology, but not functional)
01
Overview
Fc gamma receptor Ib pseudogene (FCGR1BP) belongs to the family of high-affinity Fc gamma receptors, but unlike its relatives, it is a pseudogene believed to encode a non-functional protein. It may bind the Fc region of immunoglobulin G (IgG) with low affinity, but is not detectable at the cell surface and is not considered functionally active. FCGR1BP is associated with some immune-related diseases but is not a direct therapeutic target[1][2][3][7].
- Other names
- FCGR1BCD64bFc fragment of IgG, high affinity Ib, receptorFc fragment of IgG receptor IbIgG Fc receptor IBFc-gamma RIBhFcgammaRIBIGFRBFcRIBPutative high affinity immunoglobulin gamma Fc receptor IB
02
Biological functions
Other (may function in the humoral immune response, not conclusively established)
03
Disease associations
Agammaglobulinemia 3Immunodeficiency 38 with basal ganglia calcification
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