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Target intelligence / Profile preview
Fc gamma receptor IIA (None)
- Target
- None
- Molecular classification
- Cell surface receptor, Fc gamma receptor, Receptor
01
Overview
Fc gamma receptor IIA (FcγRIIa), also known as CD32a, is a cell surface receptor that binds the Fc portion of IgG antibodies. It plays a crucial role in linking humoral immunity to cell-mediated effector functions, mediating antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and triggering the release of inflammatory mediators. The His131/Arg131 polymorphism affects binding affinity for different human IgG subclasses, influencing susceptibility to infections and autoimmune diseases, as well as clinical outcomes following therapeutic monoclonal antibody treatment.
- Other names
- CD32aFcγRIIaFCGR2A
02
Mechanism of action
Cross-linking by IgG immune complexes leads to ITAM phosphorylation and downstream signaling cascades, triggering phagocytosis, respiratory burst, and cytokine production.
03
Biological functions
Antibody-dependent cellular cytotoxicity (ADCC)Antibody-dependent cellular phagocytosis (ADCP)PhagocytosisCytokine releaseInflammatory mediator secretionImmune responseSignal transduction
04
Disease associations
InfectionAutoimmune diseasesCancer
05
Safety considerations
Adverse reactions during immunoglobulin replacement therapyAltered signaling potency among splice variants like FcγRIIA3
06
Interacting drugs
Therapeutic monoclonal antibodies
1 more in the full profile.
07
Biomarkers
His131/Arg131 polymorphism (FCGR2A)FcγRIIA3 splice variant
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