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Target intelligence / Profile preview
Fc gamma receptor IIB (FcγRIIB)
- Target
- FcγRIIB
- Molecular classification
- Receptor, Type I integral membrane glycoprotein
01
Overview
Fc gamma receptor IIB (FcγRIIB) is a low-affinity inhibitory receptor for the Fc region of immunoglobulin G (IgG). It plays a crucial role in regulating immune responses by acting as a negative regulator of cell activation, proliferation, endocytosis, phagocytosis, and degranulation. It is the only inhibitory type I human/mouse Fc gamma receptor due to its ITIM motif.
- Other names
- CD32BFCGR2BFc gamma RIIbFcgRIIbIGFRIIBCD32b/c
02
Mechanism of action
ITIM-mediated inhibition of downstream signaling pathways via recruitment of phosphatases (SHP-1/SHIP)
03
Biological functions
Negative regulation of immune cell activationRegulation of antibody productionPhagocytosisEndocytosisITIM-mediated signaling
04
Disease associations
Autoimmune diseasesSystemic lupus erythematosus (SLE)Lupus nephritisInflammatory diseasesAbdominal aortic aneurysm
05
Safety considerations
Modulation of FcγRIIB activity may have unintended consequences on immune homeostasis.Altered binding affinity for IgG subclasses due to polymorphisms can affect regulatory capacity.
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