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Target intelligence / Profile preview
Fc gamma receptor IV (FcγRIV)
- Target
- FcγRIV
- Molecular classification
- Receptor, Fc receptor, Immunoglobulin superfamily
01
Overview
Fc gamma receptor IV is a murine immune cell receptor belonging to the immunoglobulin superfamily, structurally characterized by extracellular Ig-like domains and an intracellular ITAM signaling motif via association with the Fc receptor gamma chain. It binds the Fc portion of IgG2a and IgG2b with intermediate affinity and mediates key effector functions such as phagocytosis, antigen presentation, and inflammation. FcγRIV plays a central role in antibody-dependent immune responses and contributes to both protection and immunopathology in mouse models. This receptor does not have a direct human ortholog; in humans, related functions are performed by FcγRIIIA (CD16a)[5][7].
- Other names
- FcγRIVCD16-2
02
Mechanism of action
Drugs or antibodies that engage FcγRIV induce ITAM-mediated signaling, triggering phagocytosis, cytokine release, and cell-mediated cytotoxicity
03
Biological functions
Immune responseOpsonizationPhagocytosisAntigen uptakeInflammatory signalingAntibody-dependent cellular cytotoxicity (ADCC)
04
Disease associations
InflammationAutoimmune diseaseInfection
05
Safety considerations
Manipulating FcγRIV signaling can provoke excessive inflammation or tissue damage due to its strong activation potential; animal studies highlight risk of immune hyperactivation
06
Interacting drugs
Experimentally, monoclonal antibodies and immune complexes that bind IgG2a and IgG2b subclasses interact with FcγRIV
1 more in the full profile.
07
Biomarkers
Experimental models use expression levels of FcγRIV on myeloid cells (macrophages, neutrophils) to infer immune activation status
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