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Target intelligence / Profile preview
Fc Receptor (FcR)
- Target
- FcR
- Molecular classification
- Receptor, Immunoglobulin superfamily, Type I Fc receptors, Type II Fc receptors, C-type lectin receptors
01
Overview
Fc receptors (FcRs) are a group of cell-surface proteins that specifically recognize and bind to the Fc (fragment crystallizable) region of antibodies. These receptors play a crucial role in the immune system by connecting antibody-mediated immune responses to cellular effector functions. They are implicated in various diseases and have significant therapeutic potential in areas like cancer immunotherapy and autoimmune disease.
- Other names
- Fc receptorsFc alpha receptors (FcαRs)Fc gamma receptors (FcγRs)Fc epsilon receptors (FcεRs)FcμRFcα/μRFcεRII (CD23)DC-SIGNFcRn (neonatal Fc receptor)
02
Mechanism of action
Modulation of Fc receptor signaling pathways to enhance or suppress immune responses.
03
Biological functions
Antibody-mediated phagocytosisAntibody-dependent cell-mediated cytotoxicity (ADCC)Allergic reactions and parasite defenseImmune regulationEndocytosisInflammatory responseSignal transduction
04
Disease associations
Infectious diseasesAllergic conditionsAutoimmune diseasesCancer
05
Safety considerations
Dysregulation of FcR function can lead to autoimmunity.FcεRI involvement in allergic reactions presents safety concerns related to hypersensitivity.
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