Fc receptor (Fragment crystallizable receptor) on immune cells (FcR)

The term "Fc Receptor" refers collectively to several types found mainly on immune cells such as macrophages neutrophils natural killer(NK)cells dendritic monocytes eosinophils basophils mast B-lymphocytes granulocytes platelets endothelial placental intestinal epithelial hepatocyte renal tubular epithelial fibroblast smooth muscle neuronal glial microglial osteoclast osteoblast adipocyte keratinocyte melanocyte Langerhans mesothelial synovial chondrocyte progenitor stem hematopoietic progenitor mesenchymal stromal neural progenitor embryonic pluripotent induced pluripotent somatic adult fetal cord blood bone marrow peripheral lymphoid organ spleen lymph nodes thymus tonsils Peyer’s patches appendix liver lung kidney brain skin gut mucosa reproductive tract mammary gland salivary lacrimal sweat sebaceous glands endocrine pancreas thyroid adrenal pituitary pineal hypothalamus ovary testicle prostate uterus cervix vagina fallopian tube epididym vas deferens seminal vesicle bulbourethral gland urethra bladder ureter renal pelvis calyx nephron glomerulus tubule collecting duct loop Henle distal proximal convoluted straight ascending descending thin thick limb macula dens juxtaglomerular apparatus podocyte mesangium Bowman’s capsule parietal visceral layer basement membrane capillary endothelial filtration slit diaphragm pedicel foot process slit pore fenestra tight gap adherens desmosome hemidesmosome zonula occludens adherens focal contact integrin cadherin selectin lectin mucoproteoglycan glycosaminoglycan hyaluronan collagen elast fibronectin lamin entactin vitro

Other names

Immunoglobulin Fc receptorFc gamma receptor (for IgG)Fc alpha receptor (for IgA)Fc epsilon receptor (for IgE)CD16 (FcγRIII)CD32 (FcγRII)CD64 (FcγRI)

Binding of antibody-antigen complexes to the extracellular domain of the Fc receptor triggers intracellular signaling cascades that activate immune effector functions such as phagocytosis and ADCC. Some receptors have activating motifs like ITAMs; others have inhibitory motifs like ITIMs that modulate immune responses.