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Target intelligence / Profile preview
Fc Receptor-Homolog 5 (FCRL5)
- Target
- FCRL5
- Molecular classification
- Type I transmembrane glycoprotein, Receptor, Immunoglobulin superfamily
01
Overview
Fc receptor-homolog 5 (FCRL5) is a type I transmembrane protein primarily expressed on mature human/mouse B lineage lymphocytes. It binds intact glycosylated human immunoglobulin G via a unique mechanism involving both Fab arms and the Fc region. Through its cytoplasmic ITAM/ITIM motifs it can modulate downstream signaling pathways that regulate proliferation or inhibition upon ligand engagement. Its expression marks distinct functional subsets within circulating tissue-like memory (TLM) populations—especially those expanded during chronic infection or autoimmunity—and it plays roles relevant to disease pathogenesis as well as being implicated in certain hematologic malignancies.
- Other names
- FcRH5IRTA2CD307
02
Biological functions
B cell development and differentiationRegulation of antigen receptor signalingImmune responseAntibody sensing
03
Disease associations
AutoimmunityInfectious diseasesB cell malignanciesHepatitis C virus–related mixed cryoglobulinemia vasculitis
04
Safety considerations
Potential for off-target effects due to broad IgG bindingModulation of B cell activity may lead to immune dysregulation
05
Biomarkers
FCRL5 expression level in B cells
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