Fc receptor-like 6 pseudogene (null)

The Fc receptor-like 6 pseudogene is a non-coding genomic sequence located adjacent to the functional FCRL6 locus in humans. While it shares sequence similarity to the Fc receptor-like 6 gene, it contains stop codons and/or frame-shift mutations, lacking exons necessary for transmembrane or cytoplasmic regions, and thus does not encode a functional protein. Pseudogenes of this type are generally considered nonfunctional genomic "relics" with no direct therapeutic, diagnostic, or biomarker utility. For functional studies, immunology, or therapeutic targeting, "Fc receptor-like 6" (FCRL6, ENSG00000181036) is the relevant, protein-coding gene. Fc receptor-like 6 pseudogene (ENSG00000273933) is not a therapeutic target, is not a functional receptor, and should not be considered in therapeutic or mechanistic studies related to Fc receptor-like 6 or related immunoregulatory molecules. If the intent is to refer to a drug target, the correct gene is the protein-coding FCRL6.

Other names

FCRL6PFcRL6PFCRL6-like pseudogene

null