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Target intelligence / Profile preview
Fc receptor-like protein 5 (FCRL5)
- Target
- FCRL5
- Molecular classification
- Receptor, Type I transmembrane protein, Immunoglobulin superfamily
01
Overview
Fc receptor-like protein 5 (FCRL5), also known as CD307, is a type I transmembrane glycoprotein expressed on B cells. It acts as both a negative and positive coreceptor depending on the context, playing a role in modulating B-cell responses to antigen. It contains an ITAM-like sequence and two ITIMs in its cytoplasmic tail. FCRL5 binds to intact native human IgGs, recognizing all subclasses with variable affinities. This interaction allows it to fine-tune humoral immunity by integrating signals from bound antibody ligands with those from antigen-engaged B-cell receptors.
- Other names
- CD307BXMAS1CD307eFCRH5IRTA2PRO820
02
Mechanism of action
Modulates/suppresses or enhances antigen-induced signaling in B-cells
03
Biological functions
B-cell receptor signaling modulationImmune responseSignal transductionAntibody binding
04
Disease associations
Autoimmune diseasesB-cell lymphomas
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