Target intelligence / Profile preview

Fc receptor on phagocyte (FcR)

Target: FcR
Molecular classification: Receptor, Cell surface receptor, Immunoglobulin receptor

Overview

Fc receptors (FcRs) are cell surface glycoproteins found on various immune cells, including phagocytes such as macrophages and neutrophils. Their primary function is to bind the Fc region of antibodies that are attached to pathogens or infected cells, thereby linking humoral and cellular immunity. This interaction triggers a range of immune responses, most notably phagocytosis—the engulfment and destruction of antibody-coated targets. Activation typically involves Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) within or associated with receptor subunits.

Other names: Fc gamma receptorFcγRCD64CD32CD16

Mechanism of action

N/A

Biological functions

PhagocytosisAntibody-dependent cellular cytotoxicity (ADCC)Immune responseInflammationSignal transductionCytokine releaseDegranulationImmune complex clearance

Disease associations

InfectionAutoimmune diseasesCancerInflammation

Safety considerations

Off-target effectsCytokine stormAutoimmunity

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