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Target intelligence / Profile preview
Fc receptor on phagocytes (FcR)
- Target
- FcR
- Molecular classification
- Receptor, Transmembrane protein, Immunoglobulin superfamily
01
Overview
Fc receptors (FcRs) are cell surface glycoproteins found on phagocytes that bind the Fc region of antibodies, particularly IgG, when it is complexed to antigen. This interaction triggers effector functions like phagocytosis and antibody-dependent cellular cytotoxicity. Different subtypes of FcRs exist, with varying affinities for IgG and distinct signaling properties (activating vs. inhibitory). Therapeutic strategies targeting FcRs aim to modulate immune responses in inflammatory diseases, often through competitive inhibition using IVIG.
- Other names
- Fc gamma receptorFcγRCD64 (FcγRI)CD32 (FcγRII)CD16 (FcγRIII)
02
Mechanism of action
Competitive inhibition/blockade via excess/free monomeric IgG
03
Biological functions
PhagocytosisAntibody-dependent cellular cytotoxicity (ADCC)Cytokine modulationRegulation of inflammatory responsesImmune complex clearance
04
Disease associations
InfectionAutoimmune diseasesInflammation
05
Safety considerations
Inappropriate immune activationPotential for immunosuppression
06
Interacting drugs
Intravenous immunoglobulin (IVIG)
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