FCH and double SH3 domains protein 2 (FCHSD2)

FCH and double SH3 domains protein 2 (FCHSD2) is a member of the F-BAR and double SH3-domain protein family, characterized by the presence of an N-terminal F-BAR domain and two SH3 domains[1][5]. FCHSD2 binds phosphatidylinositol phosphates, mediating its localization to membranes, and interacts with proline-rich partners such as WASP/N-WASP to stimulate actin polymerization via Arp2/3 complex activation[1][5]. In mouse cochlear hair cells, FCHSD2 regulates actin-rich structures important for auditory function[1]. It is also critically involved in clathrin-mediated endocytosis and the trafficking and recycling of receptor tyrosine kinases like EGFR in cancer cells; its loss alters receptor turnover, enhances cell proliferation and migration, and is associated with poor cancer prognosis[1]. FCHSD2 is further implicated in endosomal fission, with recruitment regulated by interactions with proteins like MICAL-L1 and intersectin-1[5]. Overall, while FCHSD2 has key adaptor and regulatory roles in membrane dynamics and cytoskeletal organization, it is not considered a classical therapeutic target such as a receptor, enzyme, or transporter[1][3][5].

Other names

FCH and double SH3 domains 2F-BAR and double SH3 domains protein 2KIAA0769SH3MD3NWK1CaromProtein nervous wreck 1SH3 multiple domains protein 3nervous wreck homologFCHSD2NWK