FCH and mu domain containing endocytic adaptor 1 (FCHO1)

FCHO1 is an endocytic adaptor protein essential for the early stages of clathrin-mediated endocytosis, acting at the plasma membrane to initiate formation of clathrin-coated pits and vesicles[1][2][3]. It contains an N-terminal F-BAR domain, a disordered linker, and a C-terminal mu-homology (μHD) domain responsible for protein–protein interactions with components such as EPS15 and AP-2[2][3]. FCHO1 regulates T cell receptor (TCR) clustering and internalization, playing a critical role in T cell activation and development[1][3]. Loss-of-function mutations cause combined immunodeficiency with B and T cell lymphopenia, susceptibility to infections, and increased risk for lymphoma[1][3]. Overexpression of FCHO1 has been linked to cell cycle progression and proliferation in lung cancer, highlighting its additional relevance in oncology[5]. FCHO1 may interact with other proteins such as AP-2 and Alk8, influencing both immune responses and cellular signaling pathways[2][3][5].

Other names

FCHO1F-BAR domain only protein 1KIAA0290IMD76FCH domain only 1FCH domain only protein 1

Modulation of clathrin-mediated endocytosis. Regulation of signal transduction pathways (e.g., PI3K/Akt/mTOR in cancer). Affecting immune cell receptor internalization and activation.