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Target intelligence / Profile preview
Fecal hemoglobin
- Molecular classification
- Other (biomarker/clinical analyte)
01
Overview
Fecal hemoglobin refers to the presence and concentration of hemoglobin found in stool samples, detected primarily through fecal occult blood tests (FOBT) or fecal immunochemical tests (FIT). It is used as a diagnostic biomarker for gastrointestinal bleeding, most notably in population screening for colorectal cancer, but may also indicate other GI conditions such as polyps, hemorrhoids, diverticulosis, and ulcerative colitis[4][5][6][3]. Quantification of fecal hemoglobin is correlated with risk of advanced neoplasia and colorectal cancer and is utilized to stratify patients for further investigation, typically via colonoscopy[2][5][1]. It is *not* a cellular protein target and does not participate directly in biological regulatory pathways.
- Other names
- FOB (Fecal Occult Blood)Stool occult bloodOccult blood testHemoccult testGuaiac smear testgFOBTImmunochemical FOBTiFOBTFIT (Fecal immunochemical test; clinically, not molecular target)
02
Mechanism of action
None (no mechanisms, this is a biomarker detected in stool)
03
Biological functions
Other (not a protein with cellular functions; detected as a marker of bleeding)
04
Disease associations
CancerInflammationCardiovascular diseaseOther
05
Safety considerations
False positives (due to non-cancerous sources like hemorrhoids, ulcers)Variability in test sensitivity based on bleeding locationDiagnostic delay if occult bleeding is not further investigated
06
Biomarkers
Fecal hemoglobin itself is a biomarker for gastrointestinal bleeding, most significantly for colorectal cancer screening
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