Fecal metabolome profile

The fecal metabolome profile represents the comprehensive set of small-molecule metabolites present in fecal samples, reflecting both host and gut microbial metabolic activity[1][6]. These metabolites are mainly products of complex interactions between the gut microbial community and the host, influenced by diet, health status, medications, and genetic background[1][3][6]. Profiling the fecal metabolome offers a functional readout of gut microbiome activity and has emerged as a promising approach for identifying novel disease biomarkers, understanding disease mechanisms, and monitoring therapeutic responses in conditions such as colorectal cancer, metabolic disorders, and inflammatory bowel disease[2][5][7]. Fecal metabolomics captures unique metabolic signatures linked to microbial species, metabolic pathways, and changes in the gut environment, providing insights complementary to those gained from genomic studies, but does not itself constitute a single molecular therapeutic target, receptor, enzyme, or transporter[1][4][6].

Other names

Fecal metabolomicsStool metabolomeFecal metabolic profilingGut metabolite profile