Fel d 1-specific CD4+ T cell receptor

Fel d 1-specific CD4+ T cell receptors are immunoreceptors expressed on the surface of CD4+ T lymphocytes that specifically recognize peptide antigens derived from Fel d 1—the major cat allergen—presented by MHC class II molecules. These T cell receptors initiate and regulate allergen-specific immune responses, most notably by promoting a Th2-polarized adaptive immune reaction that underlies IgE-mediated cat allergies and allergic asthma[1][2][3]. Fel d 1-specific T cells demonstrate a distinct memory Th2 molecular signature compared to T cells reactive to other antigens[3]. The assessment and manipulation of these receptors are important in the study and treatment of allergic diseases such as asthma and rhinitis triggered by cat exposure.

Other names

Allergen-specific CD4+ T cell receptor (where the allergen is Fel d 1)Cat allergen Fel d 1-specific T cell receptor

Recognition of Fel d 1 peptides presented by MHC class II on antigen-presenting cells, leading to CD4+ T cell activation, differentiation (primarily towards Th2 type), cytokine release, and subsequent allergic inflammation[3][2]. In allergen immunotherapy, desensitization may involve modulation of Fel d 1-specific T cell responses[3].