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Target intelligence / Profile preview
Fel d 1-Specific T Cell (N/A)
- Target
- N/A
- Molecular classification
- T lymphocyte, CD4+ T cell, T helper cell
01
Overview
Fel d 1-specific T cells are human T lymphocytes that recognize and respond to epitopes derived from Fel d 1, the major allergen produced by domestic cats. They play a central role in mediating allergic responses, particularly Th2-type responses leading to IgE production and allergic inflammation. While not a direct drug target themselves, their activity and cytokine profiles are used in diagnostics and are modulated by allergen immunotherapy.
- Other names
- Fel d 1-reactive T cellFel d 1-specific CD4+ T cellCat allergen-specific T cell
02
Mechanism of action
N/A
03
Biological functions
Antigen recognitionT cell activationCytokine production (IL-4, IL-5, IL-9, IL-13, IFNγ, IL-10)B cell helpImmune responseAllergic inflammation
04
Disease associations
Cat allergyAllergic rhinitisAllergic asthmaAtopic dermatitis
05
Safety considerations
Exacerbation of allergic reactionsCytokine storm (rare)Potential for off-target effects in immunotherapy
06
Interacting drugs
Allergen immunotherapy (Fel d 1 peptides)
3 more in the full profile.
07
Biomarkers
Fel d 1-specific T cell frequencyCytokine production profile (IL-4, IL-5, IL-13, IFNγ, IL-10)T cell receptor (TCR) repertoire
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