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Target intelligence / Profile preview
Feline Immunodeficiency Virus Envelope Glycoprotein (FIV Env)
- Target
- FIV Env
- Molecular classification
- Viral protein, Envelope glycoprotein
01
Overview
The envelope glycoprotein (Env) of the feline immunodeficiency virus (FIV) is a critical viral protein responsible for mediating the entry of the virus into host cells. Like other lentiviruses, FIV encodes a single Env precursor that is cleaved into two non-covalently associated subunits: the surface glycoprotein (SU, also known as gp95) and the transmembrane glycoprotein (TM, also known as gp35). The SU binds first to CD134 on target cells—a primary receptor unique to FIV among lentiviruses, then engages CXCR4 as a coreceptor. After receptor engagement, conformational changes in TM mediate fusion between viral and cellular membranes—enabling viral entry. Variable regions within SU—especially V3 and V5 loops—are key determinants for coreceptor usage and immune evasion.
- Other names
- FIV Envelope GlycoproteinEnv glycoproteingp95/gp35
02
Mechanism of action
N/A - Target for entry inhibitors (hypothetical)
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune evasion
04
Disease associations
Feline Immunodeficiency Virus Infection
05
Safety considerations
Antigenic variation leading to immune escapePotential for off-target effects if targeting host-like structuresDrug resistance due to mutations in Env
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