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Target intelligence / Profile preview
Feline leukemia virus subgroup C cellular receptor 1 antisense RNA 1 (FLVCR1-AS1)
- Target
- FLVCR1-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Competing endogenous RNA (ceRNA), Other
01
Overview
Feline leukemia virus subgroup C cellular receptor 1 antisense RNA 1 (FLVCR1-AS1) is a long non-coding RNA (lncRNA) located on chromosome 1q32.3, transcribed antisense to the FLVCR1 gene. It functions as a competing endogenous RNA, sequestering microRNAs (such as miR-30b-3p in glioblastoma or miR-381 in colorectal cancer), leading to derepression of oncogenic targets like E2F2 or RAP2A. Elevated FLVCR1-AS1 expression promotes tumor cell proliferation, migration, sadly, and invasion, and reduces apoptosis. Its aberrant upregulation is associated with poor prognosis in several human cancers, making it a potential therapeutic target and biomarker for cancer diagnosis and patient stratification. Note: Despite the initial user query referencing "FLVCR2-AS1," the information available in the literature pertains to FLVCR1-AS1. There appears to be either a typographical error or confusion regarding the gene symbol; thus, the canonical identity is established as FLVCR1-AS1 based on the supplied evidence[1][2].
- Other names
- FLVCR1-AS1AC007182.6FLVCR2-AS1
02
Biological functions
Regulation of cell proliferationPromotion of cell migration and invasionInhibition of apoptosisMolecular sponge for microRNAs (e.g., miR-30b-3p, miR-381)Regulation of oncogenic signaling pathways (e.g., Wnt/β-catenin, RAP2A/AKT)
03
Disease associations
Cancer - GlioblastomaCancer - Colorectal cancerCancer - Gastric cancerCancer - Hepatocellular carcinomaCancer - CholangiocarcinomaCancer - Lung cancerCancer - Ovarian cancer
04
Biomarkers
FLVCR1-AS1 expression levels as a prognostic biomarker for overall survival in cancer (e.g., colorectal cancer, glioblastoma)
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