Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Feline panleukopenia virus (FPV)
- Target
- FPV
- Molecular classification
- Virus, Family: Parvoviridae, Genus: Protoparvovirus, Species: Carnivore protoparvovirus 1
01
Overview
Feline panleukopenia virus (FPV) is a small (~20 nm), non-enveloped, single-stranded DNA virus of the Parvoviridae family that infects domestic and wild cats. FPV specifically targets rapidly dividing cells in the intestine, bone marrow, and embryonic tissues, causing destruction of white blood cells (panleukopenia), profound immune suppression, and acute gastroenteritis. The principal capsid protein, VP2, determines host range and is the main antibody target for vaccines. FPV is particularly deadly for unvaccinated kittens; the virus is highly resistant in the environment and can survive for extended periods, making outbreaks challenging to control. Current preventive measures focus on vaccination rather than direct antiviral therapy.
- Other names
- feline parvovirusfeline distemper virusFPLVFPV
02
Mechanism of action
Vaccines induce neutralizing antibodies against the VP2 capsid protein, thereby preventing infection. No direct antivirals in clinical use.
03
Biological functions
Infects and kills rapidly dividing cells (intestinal, bone marrow, embryonic tissue)Causes immune suppression via leukopeniaInduces acute gastroenteritisCauses severe disease, especially in young and immunocompromised cats
04
Disease associations
InfectionGastroenteritis and leukopenia in catsHigh morbidity and mortality in susceptible populations (kittens, unvaccinated cats)
05
Safety considerations
FPV is highly contagious and extremely resilient, surviving in the environment for yearsCats are extremely vulnerable during outbreaks especially if unvaccinatedVaccine failure due to viral evolution is a potential challenge; ongoing monitoring of FPV genomic evolution is important
06
Interacting drugs
FVRCP (feline viral rhinotracheitis, calicivirus, panleukopenia combination vaccine)
07
Biomarkers
PCR detection of FPV DNA, especially targeting the VP2 geneProfound leukopenia (decrease in white blood cell count)
Beyond the preview
Go deeper on Feline panleukopenia virus (FPV).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Feline panleukopenia virus (FPV).