Fer3-like basic helix-loop-helix transcription factor (FERD3L)

Fer3-like basic helix-loop-helix transcription factor (FERD3L) is a protein-coding gene encoding a transcription factor that functions as an inhibitor of transcription by binding to E-box sequences in DNA, requiring dimerization with an E protein for DNA binding. FERD3L acts as a negative regulator of transcription, notably inhibiting activation by ASCL1/MASH1 through sequestration of E proteins. The gene is involved in several developmental processes, especially within the nervous system, and plays a regulatory role in neurodevelopment and neuronal differentiation[1][2][3][10]. Diseases associated with FERD3L include female stress incontinence and Saethre-Chotzen syndrome, though there is currently no evidence that FERD3L is a direct therapeutic target nor that it interacts with approved drugs[2].

Other names

BHLHA31N-TWISTNATO3NTWISTbHLHa31N-TwistBasic helix-loop-helix protein N-twistClass A basic helix-loop-helix protein 31Nephew of atonal 3Neuronal twistPTFBfer3-like protein